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tahoebio/tara

v0.5.1Apache-2.0

Read-only access to Tahoe's single-cell perturbation data through the Tahoe public tools, for drug-discovery research. Look up covered drugs, doses, cell lines and genes; read drug annotations (targets, mechanism of action, approval status); and retrieve expression, drug-versus-vehicle differential expression, perturbation markers, pathway scores and embedding distance from vehicle. Read the validated signature readout for a cancer process: one per process, where one exists, in one dataset only. Compare a compound's response with annotated mechanism classes; compare drug responses between genotype- or lineage-defined groups of cell lines; correlate a cell line's baseline expression or driver-gene status with its drug response (exploratory); and rank drug-induced relative depletion and cell-cycle effects per cell line across three doses. Includes guarded read-only SQL and analysis guidance. Requires a Tahoe account; available datasets and capabilities depend on the account.

GitHub

Tara

Tara gives Claude and Codex read-only access to Tahoe Bio's single-cell perturbation data. It covers Tahoe-100M, and Emerald Bay where your account can reach it. The plugin adds a skill that guides analysis and connects to Tahoe's remote MCP server. With it you can look up drugs, cell lines and genes, read drug annotations, and retrieve expression, differential expression, perturbation markers, pathway scores and embedding distance from vehicle. For Tahoe-100M only, it also reads the validated signature readout for each cancer process: the one gene set whose VISION score tracks that process, with its evidence, direction and caveats; a process without one is reported as such, and no other set is substituted.

Install and sign in

Follow the install guide at https://tara.tahoebio.io/install.md. You add the tahoebio/tahoe-public-plugins marketplace, install the tara plugin, and then sign in with Google in the browser your client opens. You need a Tahoe account to sign in. Your account decides which datasets and releases you can use.

In Claude Code, run claude plugin marketplace add tahoebio/tahoe-public-plugins, then claude plugin install tara@tahoe-public.

Example prompts

  • Which MEK and RAF inhibitors are in Tahoe's data?
  • Does binimetinib up- or down-regulate KRAS signaling in Tahoe's data?
  • In Tahoe's data, is Pitavastatin's stronger YAP suppression than Pravastatin's driven by greater on-target activity?

Data flow

The plugin itself runs no code on your machine. Your client sends each tool call to the remote server at https://tara.tahoebio.io/mcp, which processes the tool arguments and returns results. Read the privacy policy at https://tara.tahoebio.io/privacy and the terms at https://tara.tahoebio.io/terms.

Limits

Tara is for research use only. It gives no clinical or medical advice. Every tool is read-only: it can query the data but cannot change it.

Support

Report problems at https://github.com/tahoebio/tahoe-public-plugins/issues or email tara@tahoebio.ai.

Licenses

The plugin code and manifests are Apache-2.0 (LICENSE). The skill text and documentation are CC BY 4.0 (LICENSE-CC-BY-4.0). NOTICE maps each part to its licence. Tahoe-100M data is CC0 1.0, and Emerald Bay source data is CC BY 4.0, which requires attribution. The Tahoe logo and the names "Tahoe" and "Tara" are not licensed.