tahoebio/tara

{
  "$schema": "https://agent-plugins.org/schemas/1.0.0/plugin.schema.json",
  "name": "tara",
  "version": "0.3.4",
  "description": "Read-only access to Tahoe's data through the Tahoe public tools. Use for drug-discovery analyses of large-scale single-cell perturbational transcriptomics, including a single-cell perturbation atlas. Example applications include phenotypic profiling, mechanism-of-action inference, and pathway-response and cell-state analysis. Compare a compound's expression, pathway and cell-state response with annotated mechanism classes; compare drug responses between genotype- or lineage-defined groups of cell lines; correlate a cell line's baseline expression or driver-gene status with its drug response (exploratory); and rank drug-induced relative depletion and cell-cycle effects per cell line across three doses. Look up covered drugs, doses, cell lines and genes; read drug annotations (targets, mechanism of action, approval status); retrieve expression, drug-versus-vehicle differential expression, perturbation markers, pathway scores and embedding distance from vehicle. Guarded read-only SQL and analysis guidance included.",
  "author": {
    "name": "Tahoe Bio"
  },
  "repository": "https://github.com/tahoebio/tahoe-public-plugins",
  "license": "Apache-2.0",
  "keywords": [
    "single-cell",
    "perturbation",
    "drug-discovery",
    "gene-expression",
    "pathways",
    "mcp"
  ],
  "extensions": {
    "com.tahoebio": {
      "minServerVersion": "0.3.9"
    },
    "com.openai": {
      "interface": {
        "displayName": "Tara",
        "shortDescription": "Analyze Tahoe's frontier-scale perturbation data.",
        "longDescription": "Read-only access to Tahoe's data through the Tahoe public tools. Use for drug-discovery analyses of large-scale single-cell perturbational transcriptomics, including a single-cell perturbation atlas. Example applications include phenotypic profiling, mechanism-of-action inference, and pathway-response and cell-state analysis. Compare a compound's expression, pathway and cell-state response with annotated mechanism classes; compare drug responses between genotype- or lineage-defined groups of cell lines; correlate a cell line's baseline expression or driver-gene status with its drug response (exploratory); and rank drug-induced relative depletion and cell-cycle effects per cell line across three doses. Look up covered drugs, doses, cell lines and genes; read drug annotations (targets, mechanism of action, approval status); retrieve expression, drug-versus-vehicle differential expression, perturbation markers, pathway scores and embedding distance from vehicle. Guarded read-only SQL and analysis guidance included.",
        "developerName": "Tahoe Bio",
        "category": "Research",
        "capabilities": [
          "Read"
        ],
        "websiteURL": "https://tara.tahoebio.io/",
        "brandColor": "#082846",
        "composerIcon": "./assets/tahoe-logo.png",
        "logo": "./assets/tahoe-logo.png",
        "defaultPrompt": [
          "Which MEK and RAF inhibitors are in Tahoe's data?",
          "In Tahoe's data, is Pitavastatin's stronger suppression of YAP signaling than Pravastatin driven by greater on-target activity?",
          "Does binimetinib up- or down-regulate KRAS signaling in Tahoe's data?"
        ]
      }
    }
  }
}