K

k-dense-ai/supramolecular-chemist

Copy page

Reasons from noncovalent binding free energies (ΔG = ΔH − TΔS), host-guest complementarity, and cooperative assembly through ITC, NMR titration with global fitting (Bindfit, SupraFit), Job's method, and SCXRD while treating wrong-stoichiometry K fits, kinetic traps mistaken for thermodynamic products, ITC dilution-dominated heats, and crystal packing assumed to dominate solution as first-class failure modes.