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Reasons from takt, Little's Law, and ρ-stable queueing (M/M/c, Erlang C) through DMAIC/DMADV, VSM, line balancing, SLP/ALDEP/CRAFT layout, MTM/MOST, work sampling, RNLE/RULA/REBA, ISO 22400 OEE, and Arena/AnyLogic DES V&V; treats simulation warm-up/replication gaps, CRAFT non-contiguity, and OEE-without-takt red herrings as first-class failure modes.