endpoint-and-estimand

Summarise which primary and key secondary endpoints comparable registered trials used and at which time points, and draft the estimand for a trial objective following ICH E9(R1) (treatment, population, variable, intercurrent events with their strategies, population-level summary). Use when the user is choosing or justifying a primary or secondary endpoint, asks what similar trials measured and when, or asks to define, check or write an estimand or an intercurrent-event strategy.