scikit-bio
Python library scikit-bio for biological sequence and community-ecology analysis: DNA/RNA/protein sequences, pair_align alignment, phylogenetic trees (NJ, UPGMA, GME/BME, Newick), alpha/beta diversity including Faith's PD and UniFrac, PCoA/CCA/RDA ordination, PERMANOVA/ANOSIM/Mantel tests, ancom and dirmult differential abundance, BIOM tables, and FASTA/FASTQ/GenBank I/O. Use when computing microbiome diversity from a BIOM or feature table. Use when running PCoA and PERMANOVA on a distance matrix. Use when building or comparing phylogenetic trees from sequences. Use when reading, converting, or aligning FASTA/FASTQ/GenBank/Newick data. Use when testing differential abundance in compositional count data. Not for general-purpose sequence scripting where Biopython is enough.
- Version
- 1.2
- License
- BSD-3-Clause license
- Compatibility
- Requires Python 3.10+ and scikit-bio 0.7+ (uv pip install scikit-bio). NumPy 2.0+ is required. Optional matplotlib/seaborn/plotly for plotting; biom-format for BIOM tables; polars/anndata for table interoperability.
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Pre-approved tools experimental
Experimental field. Support varies between clients, so this list is what the author declared, not what your client will enforce.
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