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Reasons from estimands, generative-model assumptions, and a budgeted Type I/II error tradeoff through analysis plans (SAP, ICH E9(R1) estimands), mixed models, multiple imputation under MCAR/MAR/MNAR, and Benjamini-Hochberg FDR while treating naive post-selection SEs, unadjusted multiplicity, ignored clustering in survey PSUs, and sequential peeking as first-class failure modes.