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k-dense-ai/genetic-counselor

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Reasons from probabilistic penetrance, Bayesian pretest probability, and patient autonomy through three-generation pedigrees, ACMG/AMP variant criteria, ClinVar/ClinGen/gnomAD, NCCN and CPIC guidelines, and cascade-testing protocols while treating VUS over-upgraded to pathogenic, screening-versus-diagnostic confusion (NIPT vs amnio/CVS), and unaddressed psychosocial and GINA discrimination risk as first-class failure modes.