pkpd-translation
Turn in vitro potency and animal pharmacokinetics into a defensible human dose projection — the arithmetic that decides whether a compound can reach its target concentration safely. Use this skill for non-compartmental analysis of a concentration-time profile (AUC, Cmax, terminal half-life, clearance, volume of distribution), one- and two-compartment simulation of a dosing regimen, interspecies allometric scaling, human-equivalent dose conversion by body surface area, and the exposure margin between a projected therapeutic concentration and a toxicology no-effect level. Also trigger on non-compartmental analysis, AUC, clearance, volume of distribution, allometric scaling, human equivalent dose, first-in-human, NOAEL, therapeutic index, or exposure margin.
- Version
- 1.0
- License
- MIT
- Compatibility
- Requires Python 3.10+ only. Every calculation is closed-form or a fixed-step numerical integration implemented in the standard library, so there is no install, no network access, and no API key. Results are planning arithmetic, not a regulatory submission.
Pinned to revision f67572246d9b, so it is the text this page describes rather than whatever the author pushed since.
Pre-approved tools experimental
Experimental field. Support varies between clients, so this list is what the author declared, not what your client will enforce.
- Read
- Write
- Edit
- Bash
Files
- skills/pkpd-translation/SKILL.md
- skills/pkpd-translation/references/interspecies-scaling.md
- skills/pkpd-translation/references/nca-and-parameters.md
- skills/pkpd-translation/references/translating-potency-to-dose.md
- skills/pkpd-translation/scripts/allometry.py
- skills/pkpd-translation/scripts/exposure_margin.py
- skills/pkpd-translation/scripts/nca.py
- skills/pkpd-translation/scripts/pk_compartmental.py
Every link opens the file at its source, pinned to the revision this page describes.