glycoengineering
Analyze and engineer protein glycosylation. Scan sequences for canonical N-glycosylation sequons (N-X-S/T with X not proline, including overlapping sites), predict O-GalNAc hotspots, read glycan notation, and reach the curated external tooling (NetNGlyc, NetOGlyc, GlycoShield, GlycoWorkbench, GlyTouCan, GlyConnect). Use this skill for therapeutic antibody glycoengineering and afucosylation for ADCC, Fc glycan control, glycan shielding in vaccine immunogen design, sequon removal or insertion, and half-life engineering through sialylation. Also trigger on N-glycosylation, sequon, NXS/NXT, O-glycosylation, glycoform heterogeneity, afucosylation, high-mannose, GlyTouCan, or WURCS.
- Version
- 1.2
- License
- MIT
- Compatibility
- Requires Python 3.10+. The bundled sequon and notation analysis is standard library only. Optional extras — pandas and requests for the database lookups, glycoshield for ensemble modelling. The external predictors (NetNGlyc, NetOGlyc) are DTU web services requiring manual submission and, for some, an academic licence; there is no public REST API.
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Pre-approved tools experimental
Experimental field. Support varies between clients, so this list is what the author declared, not what your client will enforce.
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