depmap
Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), RNAi DEMETER2 scores, PRISM compound sensitivity, and gene effect profiles across the cell-line panel. Use for identifying cancer-selective vulnerabilities, separating pan-essential genes from selective ones, finding synthetic lethal interactions, correlating dependency with mutation, expression and copy number, and validating oncology drug targets. Also trigger on DepMap, Chronos gene effect, CRISPRGeneEffect.csv, DEMETER2, PRISM repurposing, co-essentiality, pan-essential, or ACH- cell line identifiers.
- Version
- 1.1
- License
- MIT
- Compatibility
- Requires Python 3.10+ with pandas, numpy, scipy and requests. Analysis is download-based — the DepMap release files (CRISPRGeneEffect.csv is roughly 500 MB) are fetched from the portal by hand and read locally. The portal gates programmatic access behind a browser verification page, so there is no usable REST API. Data is CC-BY-4.0 and requires registration to download.
Pinned to revision f67572246d9b, so it is the text this page describes rather than whatever the author pushed since.
Pre-approved tools experimental
Experimental field. Support varies between clients, so this list is what the author declared, not what your client will enforce.
- Read
- Write
- Edit
- Bash
Files
Every link opens the file at its source, pinned to the revision this page describes.